研究发现性别,年龄和种族与结直肠癌生存
性别,年龄和种族的互动对转移性结肠直肠癌的整体生存(MCRC)患者的互动,由南加州大学(USC)和USC / Norris综合癌症中心的研究人员领导的研究。
While age and ethnicity are well-established factors that impact survival in colorectal cancer, the study found that gender also plays an important role in overall survival, says Andrew Hendifar, M.D., MPH, fellow in the division of hematology/oncology at the Keck School of Medicine of USC and lead author of the study. Researchers found that pre-menopausal women with metastatic colorectal cancer (18-44 years old) lived longer than younger men, while older women (75 and older) had significantly worse overall survival than older men.
该研究的结果将在6月1日星期日讨论2008年6月1日的2008年美国临床肿瘤学会年会(ASCO)的海报讨论,在芝加哥McCormick Place举行。
研究人员表示,该研究增加了越来越多的证据表明女性荷尔蒙对结肠癌进行保护性。
"This study provides further evidence that estrogen may play an important role not only in colon cancer development but also progression of the disease, and may impact how we develop therapies for women and men with colon cancer," says Heinz-Josef Lenz, M.D., professor of medicine at the Keck School of Medicine and a senior investigator on the study.
研究人员从1988年到2003年筛选了56,598名患者,从1988年到2003年,使用监测,流行病学和最终结果(SEER)登记处。模型是使用诊断,性别,种族和整体生存的患者年龄来创建的。与年龄无关,男女与MCRC之间没有生存差异。然而,当年龄加入模型时,性别与所有种族的生存显着相关。
研究人员还发现,某些种族的整体生存比其他种族更好。即,西班牙裔和亚洲人比高加索人和非裔美国人有更好的结果。该领域的进一步研究应了解某些饮食或特定环境如何有助于亨德纳群系的发展。
“数据保证进一步研究,以确定雌激素和种族在结肠直肠癌发展中的作用,”他说。“在未来,我们可能为男女量身定制不同的治疗方法。”
资料来源:南加州大学
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