富国女性的生存减少了“三负”乳腺癌亚型

根据第三次AACR会议的一项研究，普拉特氏患者缺乏雌激素和孕酮受体，并且没有过度表达Her2neu蛋白（三阴性）的存活率比其他类型的侵袭性乳腺癌更差癌症健康障碍科学，举行9月30日至10月3日。

“作为发病率乳腺癌rises in Puerto Rico, following U.S. trends, it is important to understand the association of disease subtypes with survival," said Ana P. Ortiz Martinez, M.P.H., Ph.D., associate professor and researcher at the University of Puerto Rico Cancer Center and the department of biostatistics and epidemiology, Graduate School of Public Health, University of Puerto Rico. "Breast cancer is a complex disease, with distinct subtypes with widely differing therapeutic indications and临床结果。“

这是第一次发表关于肿瘤亚型和其他临床因素对波多黎各乳腺癌生存的影响。

研究人员分析了974名女性患者的数据侵袭性乳腺癌从2000年到2005年，谁被诊断出诊断和治疗了Puerto Rico的主要医院。

乳腺癌死亡率的风险患有三重阴性乳腺癌亚型的妇女死亡患者与其他肿瘤亚型的两倍多，甚至在诊断妇女的年龄和癌症阶段核算后也是妇女。

在诊断时50岁或更年轻的女性也更有可能因其乳腺癌而死亡。

研究的女性患有22.5％的乳腺癌，乳腺癌是Her2neu阳性的（意味着它过度表达这种蛋白质）;60.9％的乳腺癌对雌激素或孕酮受体呈阳性，但对Her2neu是阴性的;16.6％的是三重阴性，既不过表达Her2neu也不接受雌激素或孕酮。

Findings, which were consistent with results described in previous studies of U.S. populations, will be useful in the development of cancer control strategies in Puerto Rico and may have an impact on future studies of targeted therapies to improve breast cancer survival in other Hispanic populations, said Ortiz Martinez.

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