阿尔茨海默病风险的结构脑改变

People at risk of developing Alzheimer’s disease exhibit a specific structural change in the brain that can be visualized by brain imaging, according to new research presented at Neuroscience 2010, the annual meeting of the Society for Neuroscience and the world’s largest source of emerging news about brain science and health. The findings may help identify those who would most benefit from early intervention.

“Our findings support the notion that structural imaging techniques can be used to identify people at risk for developing Alzheimer’s disease,” said Sarah George, a graduate student who co-authored the study with Leyla deToledo-Morrell, PhD, of Rush University Medical Center.

研究人员跟随人们具有轻度认知障碍的人，这种病症可能是阿尔茨海默病的前身和其他形式的痴呆。一些参与者继续开发阿尔茨海默病，其他人没有。

研究人员使用磁共振成像（MRI）来寻找体积Innominata（Si）的结构变化，大脑内部的区域，将化学信号送到脑皮层，脑在很大程度上负责推理，内存和其他“更高功能”任务的外层。虽然在Si中没有发现结构变化，但MRI表现出皮质区域的减薄，这些皮质区域接收来自SI的患者在那些继续开发阿尔茨海默病的人。

“MRI筛查似乎是阿尔茨海默病的早期生物标志物的强烈候选者，”乔治说。

国家老龄化研究所和伊利诺伊州伊利诺伊州伊利诺伊州南部疾病援助中心的伊利诺伊州伊利诺伊州的伊利诺伊州疾病援助中心的支持得到支持。

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