研究人员发现吸烟可能会增加肺病的风险
A team of researchers at Brigham and Women’s Hospital (BWH) have found that approximately one out of every twelve adult smokers have abnormal lung densities present on chest computed tomography (CT) images suggestive of interstitial lung disease which is associated with substantial reductions in lung volumes. In addition, despite being positively associated with smoking, these lung densities were inversely not associated with emphysema. This research is published online on March 10th in the新英格兰医学杂志。
越来越公认的是间歇性的肺部疾病可能在发育症状之前发展。虽然众所周知,吸烟会导致某种形式的间质性肺病,但这些胸部CT扫描异常的患病率及其对肺体积的影响尚不清楚。“这款手稿突出了与以前未被吸烟者中以前未被识别的间质肺异常相关的肺部体积减少程度,”BWH放射学和肺部/临界护理医学分区的MD和Ivan ROSAS,MD表示。
在这项研究中,研究人员的特征在于2416名参与者的间质肺异常存在来自Copdgene研究。研究人员发现,间质肺异常与吸烟者的总肺容量和较低的肺气肿有关。该团队还发现,具有间质性肺异常的吸烟者患有限制性降低的肺氧气量的风险增加。
“吸烟可能导致不同的事实,并且在某种程度上,生理性不同的肺部条件强调了更好地理解可以易受的表型,环境和遗传背景的需要吸烟者肺病多种肺病,“乔治沃基·麦克斯科,麦克兰·彭宁哈克,MD,在BWH的肺部/关键护理医学分裂。
需要进一步研究,以肯定表征胸部CT和特发性肺纤维化的间质肺异常之间的联系,最常见的间质性肺病。
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