叶酸，维生素B6和12不会影响结肠直肠腺瘤风险

根据10月12日公布的一项研究，联合叶酸，维生素B6和维生素B12补充剂对心血管疾病高风险的患者患有高风险的风险没有统计学显着影响。国家癌症研究所杂志。

据报道，28％至35％的美国人口占含有叶酸，维生素B6的膳食补充剂和维生素B12.，之前的体外和动物研究表明B族维生素作用结直肠癌，以及一些观察性流行病学研究建议在摄入最高的叶柄中的个体风险20％-40％，但大多数随机对照试验专注于叶酸补充剂。In order to determine the potential effects of folic acid, vitamin B6 and vitamin B12 on the risk of colorectal adenoma—a precursor to colorectal cancer— Yiqing Song, M.D., Sc.D., of the Harvard Medical School in Boston and colleagues conducted a study in the Women's Antioxidant and Folic Acid Cardiovascular Study (WAFACS), a randomized, double-blind, placebo-controlled trial which looked at 5,442 female health professionals who were at high risk for cardiovascular disease. The participants in the WAFACS, which took place between April 1998 and July 2005, were randomly assigned to a combination of folic acid, vitamin B6 and vitamin B12, or placebo. This analysis included 1,470 WAFACS participants who received a follow-up endoscopy at some point during the 9.2-year follow-up period.

研究人员发现，妇女结直肠腺瘤的风险没有统计学显着影响联合叶酸的摄入量维生素B6和维生素B12补充。“我们的发现不支持推荐B-维生素补充为了预防结肠直肠腺瘤，“研究人员写作，增加了更多的证据，以验证他们的发现。他们还发现，已知是叶酸”拮抗剂“的酒精消耗并未影响补充剂对结直肠的影响腺瘤风险。

In an accompanying editorial, Regina G. Ziegler, Ph.D., M.P.H., of the Division of Cancer Epidemiology and Genetics writes that the null results of the trial, that high doses of folic acid did not increase risk of colorectal adenoma during up to nine years of follow-up, are reassuring with respect to the US decision to fortify cereal-grain products with folic acid, beginning in 1998, to reduce neural tube defects. However, the null results are less pertinent to the protective potential of folate, B6, and B12 when given to men and women with suboptimal micronutrient intake. "Observational epidemiology results, from prospective studies of diet and supplements or of circulating biomarkers, are provocative and imply that the role of folate and other B vitamins in colorectal carcinogenesis merits continued exploration."

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