加巴亨坦不会削减使用吗啡骨骼关节造身术

根据11月20日发表在《每日健康》杂志上的一项研究，在患者自控镇痛(PCA)方案中添加加巴喷丁并不能减少接受全膝关节置换术患者的吗啡消耗量、疼痛或阿片类药物相关副作用骨关节手术杂志。

In an effort to examine whether gabapentin reduces morphine consumption, James E. Paul, M.D., from McMaster University in Hamilton, Canada, and colleagues conducted a randomized trial involving 101 patients (mean age, 63 years; 63 percent women) who were receiving total knee arthroplasty. All participants received acetaminophen and intravenous ketorolac two hours before surgery, and after surgery they received PCA morphine for three days, and acetaminophen and ketorolac. In addition, participants were randomized to receive pre- and postoperative gabapentin (52 patients) or placebo (49 patients).

研究人员发现，在72小时内吗啡的累积消耗量方面，两组之间没有差异(加巴喷丁组为66.3 mg，安慰剂组为72.5 mg)。两组之间也没有差异疼痛休息，运动或重量轴承分数。在这两组中，恶心，呕吐，瘙痒，头晕或光敏性的发病率和视觉紊乱是相似的。在放电时，组在膝关节范围内没有差异。

“病人膝盖总关节造形术，添加加巴喷丁的主成分分析协议没有减少吗啡的消耗量，疼痛，或阿片类药物相关的副作用，”作者写道。

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