雌激素和孕激素的连续使用降低了绝经后妇女的欧共体风险
在12月14日公布的一项研究中,已显示连续孕激素向雌激素缩短绝经后妇女的子宫内膜癌症的风险JNCI:国家癌症研究所杂志。
添加普利汀对A.雌激素众所周知,方案可降低风险子宫内膜癌症这与雌激素单独使用有关,但只有孕激素的添加量降低了使疾病的风险仍然不清楚。
In order to determine the effects that continuous estrogen plus progestin use has on the risk of endometrial cancer, Rowan T. Chlebowski, M.D., Ph.D., Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, and colleagues reviewed data from a randomized clinical trial by the Women's Health Initiative (WHI) that assessed 16,608 postmenopausal women aged 50-79 with intact uteri. All participants were required to have a normal endometrial biopsy on entry and were randomly assigned to daily estrogen plus progestin (given as one pill) or placebo (no hormones) and followed over a period of 13 years.
研究人员发现,在接受组合雌激素加上孕激素治疗的小组中,子宫内膜癌症发生率有统计学显着降低了子宫内膜癌症发病率,并且在13年的累积后续服用孕激素治疗(33例,每年0.06%)那些接受安慰剂的人(每年95例,每年0.10%)。“连续组合雌激素加上孕激素使用5.6岁,治疗中具有正常子宫内膜活检的后期妇女导致子宫内膜癌症发病率的统计显着降低,在长期干预后续期间,差异变得统计学意义,”作者写下,添加那个,“绝经后妇女,连续组合的雌激素加上孕激素使用可降低子宫内膜癌症发病率35%。“
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