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class="article__info mb-2"> <div class="article__info-item mr-auto"> <a href="//www.puressens.com/archive/10-08-2017/" rel="nofollow"> <svg class="article__info-icon"> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_clock" x="0" y="0"></use> </svg></a> <p class="text-uppercase text-low">2017年8月10日,< /p> </div> </div> <h1 class="text-extra-large line-low mb-2">新的见解的免疫细胞是如何形成的< /h1> <p class="article-byline text-low">通过<a class="article-byline__link" href="http://www.uu.se/en/" target="_blank">乌普萨拉大学< /a></p> <div class="mt-4 article-main"> <p>与此前认为,血液干细胞转变为肥大细胞的发展,一种特殊的免疫细胞,不依赖于干细胞因子。这已经证明了一个新的卡罗林斯卡医学院和乌普萨拉大学的研究人员合作研究,并发表在《科学》杂志上<i>血< /i>。结果可能为某些类型的血液疾病的新疗法。< /p> <div class="article-banner first-banner ads-336x280">  <div id="div-gpt-ad-1450190541376-1"></div> </div> <p>过敏和哮喘影响的人口比例很高。桅杆<a href="//www.puressens.com/tags/cells/" rel="tag" class="textTag">细胞< /a>是专门的<a href="//www.puressens.com/tags/immune+cells/" rel="tag" class="textTag">免疫细胞< /a>不仅扮演着重要的角色在这些条件还在肥大细胞增多症等其他疾病,疾病血液疾病过程涉及一个数量的增加<a href="//www.puressens.com/tags/mast+cells/" rel="tag" class="textTag">肥大细胞< /a>。一般理解,生长因子干细胞因子,刺激肥大细胞的发展,对肥大细胞的形成至关重要。现在卡罗林斯卡医学院和乌普萨拉大学的研究人员已经表明,情况并非如此。研究人员分析了肥大细胞和他们的祖细胞在慢性髓系白血病患者的血液,血液的一种疾病。< /p> <p>“当患者接受药物伊马替尼(Glivec),哪些块干细胞的影响因子,成熟的肥大细胞的数量下降,而祖细胞的数量并没有改变。我们因此可以得出这样的结论:肥大细胞祖细胞不需要干细胞因子”,医学系的贡纳·尼尔森教授说,索尔纳,和系统性肥大细胞增多症的卓越中心在卡罗林斯卡医学院,医学科学学系客座教授,乌普萨拉大学,他领导了这一研究。< /p> <p>由柱状细胞培养<a href="//www.puressens.com/tags/progenitor+cells/" rel="tag" class="textTag">祖细胞< /a>存在于血液,相对少见(大约10细胞每百万<a href="//www.puressens.com/tags/white+blood+cells/" rel="tag" class="textTag">白细胞< /a>),研究人员发现肥大细胞祖细胞可以存活,分裂和部分成熟干细胞因子。相反,开发可以发生的因子白介素3和6。< /p> <p>“这项研究增加了我们理解的肥大细胞是如何形成的,可能是重要的新疗法的发展,例如为肥大细胞增多症治疗伊马替尼/ Glivec不是有效的。现在一个假设,我们将测试是白介素3能否成为新的目标在桅杆cell-driven疾病的治疗”,评论乔阿欣Dahlin,医学系的研究员,索尔纳,在卡罗林斯卡医学院及这项研究的第一作者。< /p> <hr> <div class="article-main__explore my-4 d-print-none"> <div class="d-flex align-items-center"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#plus" x="0" y="0"></use> </svg> <p class="text-bold mb-0 ml-2">进一步探索< /p> </div> <a class="text-medium text-info mt-2 d-inline-block" href="//www.puressens.com/news/2017-05-proof-of-principle-imatinib-symptoms-patients.html">的证据原则研究发现伊马替尼严重哮喘患者改善症状< /a> </div> <hr class="mb-4"> <div class="article-main__more p-4"> <strong>更多信息:< /strong>乔阿欣Dahlin et al。设备信号是可有可无的人类肥大细胞祖发展<i>血< /i>(2017)。<a data-doi="1" href="http://dx.doi.org/10.1182/blood-2017-03-773374" target="_blank">DOI: 10.1182 / - 2017 - 03 - 773374血< /a> <div class="mt-3"> <strong>期刊信息:< /strong> <a href="//www.puressens.com/journals/blood/"><cite>血< /cite></a> <a class="icon_open" href="http://bloodjournal.hematologylibrary.org/" target="_blank" rel="nofollow"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_open" x="0" y="0"></use> </svg></a> <p></p> </div> </div> <div class="d-inline-block text-medium my-4"> 所提供的<a href="//www.puressens.com/partners/uppsala-university/">乌普萨拉大学< /a> <a class="icon_open" href="http://www.uu.se/en/" target="_blank" rel="nofollow"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_open" x="0" y="0"></use> </svg></a> </div>  <div class="d-none d-print-block"> <div class="mb-4"> <strong>引用< /strong>:新的见解的免疫细胞是如何形成的(2017年8月10日)检索2022年6月4日从//www.puressens.com/news/2017-08-insight-immune-cells.html< /div> <div class="border text-muted p-3"> 本文档版权。除了任何公平交易私人学习或研究的目的,没有书面许可,不得部分复制。内容只提供信息的目的。< /div> </div> </div> </article> <div class="article-interaction my-4 d-flex align-items-center d-print-none"> <a href="javascript:void(0)" class="btn btn-info px-4 py-2 text-regular border-0 mr-4"><span>1< /span>股票< /a> <ul class="ml-md-auto ml-sm-0 article-interaction__social d-flex"> <li><a href="javascript:void(0)" class="article-interaction__link fb"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_fb_news" x="0" y="0"></use> </svg><p class="text-regular mb-0">脸谱网< /p></a></li> <li><a href="#" class="article-interaction__link tw" data-title="New insight into how immune cells are formed" data-via="medical_xpress"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_twit_news" x="0" y="0"></use> </svg><p class="text-regular mb-0">推特< /p></a></li> <li><a href="#" class="article-interaction__link" data-toggle="modal" data-target="#feedback-email"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_mail_news" x="0" y="0"></use> </svg><p class="text-regular mb-0">电子邮件< /p></a></li> </ul> <a href="#" class="ml-auto mt-lg-4 mt-xl-0 article-interaction__link" data-toggle="modal" data-target="#feedback-to-editors"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_feedback" x="0" y="0"></use> </svg><p class="text-regular mb-0">反馈给编辑< /p></a> </div> </div> </div> </section> </div>  <div class="offset-xl-1 col-md col-lg-4 col-xl-3 article-sidebar d-none d-lg-block 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