Antimicrobial gel could improve root canal results

More than 15 million root canals are done each year, according to the American Association of Endodontists. During the procedure, the tooth's pulp and nerve are removed before the tooth is cleaned and sealed. If bacteria, viruses or yeasts contaminate the tooth, another root canal procedure or surgery must be done.

Now, the results ofroot canaltreatments could improve because of an antimicrobial gel discovered and developed at the Indiana University School of Dentistry.

Ghaeth H. Yassen, a visiting assistant professor, has developed an injectable antimicrobial gel that could disinfect a tooth during a rootcanalprocedure.

"I wanted to create a gel that provides sustainedantimicrobial propertieseven when it is removed. I also wanted it to have minimal toxic effect on stem cells and not causetoothdiscoloration," he said. "Creating an antimicrobial space is especially important during clinical regenerative endodontic procedures."

Yassen said the gel has advantages over traditional medications, including calcium hydroxide, widely used as an antibacterial agent.

"The gel offers extended and significantly longer residual antibacterial properties, which has been proven in papers published in theJournal of Endodonticsand theInternational Endodontic Journal," he said. "It is biocompatible, and it contains a low concentration of antimicrobial elements."

Yassen said the next steps include optimizing a version of the gel that is opaque to X-rays and other radiation, which will enable dental care professionals to track it within the root canal system.