图1.异源突触形成中PTPσ信号通路的分子模型。通过细胞外和细胞内信号传导组分的组合,PTPσ触发兴奋性异源突触形成。PTPσD2结构域结合细胞内衔接子(例如,Liprin-α)和底物(例如,P250RHoGap和N-Cadherin),以募集兴奋性突触发育的凹凸机械。This signal transduction model differs from that of neurexin.B) Neurexins serve as anchor proteins that transduce postsynaptic signals from various ligands (e.g., neuroligins and leucine-rich repeat transmembrane proteins) and transfer them to adjacent, but as yet unidentified, coreceptor protein(s) to mediate the signal transduction cascades necessary for full heterologous synapse formation activity. Credit: Daegu Gyeongbuk Institute of Science and Technology (DGIST)
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