过量,停用丁丙诺啡后复发
(HealthDay)根据12月2日在线发表的一项研究,阿片类药物过量后,丁丙诺啡治疗可能需要数年,以减少过量和其他不良事件的风险美国精神病学杂志。
Arthur Robin Williams, M.D., from the New York State Psychiatric Institute at the Columbia University Medical Center in New York City, and colleagues used the MarketScan multistate Medicaid claims database (2013 to 2017) to identify adults (18 to 64 years of age) who received buprenorphine continuously for ≥180 days. Outcomes were assessed by buprenorphine duration period (six to nine months, nine to 12 months, 12 to 15 months, and 15 to 18 months).
研究人员发现,不良事件在所有队列中都是常见的,几乎一半的患者(42.1 - 49.9%)至少在急诊科看过一次。保留15至18个月的患者(931例)的风险显著降低急诊科与保留在丁丙诺啡患者六至九个月(4,126名患者)的患者相比,访问(差距比例,0.75),填充阿片类药物(差距,0.79)和填充阿片类药物处方(差异,0.67),而在丁丙诺啡患者(4,126名患者)。跨越群组,大约5%的患者经历了一种或多种医学治疗的过量。
“患者和家属需要指导,社会支持Williams在一份声明中说到。
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