双产前治疗比单独或没有益处的极端早产儿

称为极其早产儿的微小婴儿具有非常低的出生体重，欠发达的器官，以及长期问题或残疾的风险。出生前给予的母亲和胎儿治疗的产前治疗 - 提供了改善早产儿的结果。

产硫酸镁或硫酸镁产前皮质类固醇有知名的好处，以减少问题脑瘫， 死亡，呼吸窘迫综合征或坏死性小肠结肠炎，并为妊娠24至33周之间出生的婴儿建议进行两种治疗。它们两者的效果在极其早产孩子们，除了单独或无，尚未研究，但两者常常在常规护理中给予。

Now researchers, led by Samuel Gentle, M.D., assistant professor of pediatrics in the University of Alabama at Birmingham School of Medicine, report that antenatal treatment with both magnesium sulfate and corticosteroids together yields an increased benefit for children born at 22 to 26 weeks of gestation, compared to no antenatal treatment or with either therapy alone. This multi-center, prospective observational study included six universities, a nonprofit research institute and the National Institutes of Health Neonatal Research Network. Researchers did a statistical analysis of medical records for 3,093 children born 2011 through 2014, which included comprehensive neurodevelopmental follow-ups at 18 to 26 months of corrected age. The children had an average birth weight of 1 pound, 9 ounces.

暴露于产前皮质类固醇和硫酸镁的儿童具有36.3％的严重神经发育损伤或死亡率，而44.3％，对于暴露于产前皮质类固醇的人，对于暴露于硫酸镁的人，对于那些既没有的人则为48.2％治疗。

同样，儿童暴露于产前皮质类固醇和镁与或两种治疗相比，硫酸率较低的死亡率。然而，幸存者中严重的神经发育损伤率在暴露组中没有差异。

该研究发表在期刊上妇产科温和讨论了这些发现的重要性临床实践在最近的“编辑选择”播客：“你可能会说，'如果有数据支持两者的练习，我们需要看看这个吗？'在这个队列中，大约75％的婴儿暴露于硫酸镁，而近90％暴露于产前皮质类固醇。如果有时间进行一次治疗，似乎有时间接触到两者。“

"This national research is a very important study of two of the most effective maternal medications in periviability," said one of the co-authors, Waldemar Carlo, M.D., the Edwin M. Dixon Professor of Pediatrics and director of the UAB Division of Neonatology and Newborn Nurseries.

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