植入式无线导管血氧仪用于外科手术过程中心脏生理的实时监测。(A)心脏表面附近无线血氧测量植入装置的使用示意图。该系统由一个导管式血氧仪组成,传感尖端缝合在心脏表面,与附着在皮肤上的电子模块连接,通过蓝牙协议进行信号采集和无线数据传输。自定义GUI在计算机上显示和记录数据,并作为设备的控制接口。(B和C)设备设计爆炸图示意图。(B)电子模块包含五层:底部弹性体基板,柔性PCB,一组电子元件,锂离子电池和顶部弹性体封装。(C)放大图像显示传感器探头,由柔性PCB、光刺激和传感组件和光阻塞模块组成。该探针直径为1.5毫米,完全封装了透明的、生物相容的硅胶。(D)环绕玻璃棒的导管血氧计图像。(E)未经封装的电子模组图像。 (F) Image of a catheter-type oximetry sensor. (G) Schematic block diagram of the system. Photo credit: Wei Lu and Wubin Bai, Northwestern University. Credit: Science Advances, doi: 10.1126/sciadv.abe0579
光学,热和电子特性。(a)用于传感器探头的红色和NIR LED的光发射的光谱特性。这些LED(645和950nm的峰值波长)覆盖了Hb和HbO2的反向吸收性能的谱的部分。(b)测量光电流作为红色和NIR LED的输入电流的函数,传感器探针注入到生肉中。实验设置出现在图2中。S3。(c)从心脏组织中NIR和红色LED的归一化发光强度谱的空间分布的蒙特卡罗模拟。(d)热图像,显示成年臂的皮肤温度分布,其中导管探针放在顶部。(e)在操作期间测量血氧计传感器探针的温度,在1分钟内激活并在4分钟内去激活。传感器在温度(小于0.08°C)中均匀增加。 (F) Measured photovoltage output from the amplifier circuit as a function of time during a driving clock sequence of red and NIR LEDs and ADC sampling. Narrowing the driving pulses for the LEDs effectively reduces the power consumption and prolongs battery lifetime. (G) Battery voltage as a function of working time. A 45-mAh lithium battery supports operation for at least 22 hours. Credit: Science Advances, doi: 10.1126/sciadv.abe0579
机械封装和生物相容性特性。(a)测量三个导管探针的杨氏模胶(INSET图像;鳞片棒,2厘米)包封有三种不同的生物相容性有机硅弹性体(标有三种不同的生物相容的硅氧烷弹性体(标有Med-1040,Med-1000和Med-1037)。三个导管探头的杨氏的模胶在800至1700kPa的范围内。(b)(a)中的三个导管探针的测量弯曲刚度,由封装用Med-1000的相对硬铜线和商业光纤导管(Swan Ganz 777f8,Edwards Lifesciences Inc.)制成的导管探针。弯曲刚度分别为1.6,1.8,2.3,20和243n / mm2。(c)传感器探针和导管分别经受弯曲半径为22和27mm的有限元建模。(d)测量来自导管探针的光电电压作为压缩循环和弯曲的函数。实验细节出现在图1和2中。S7和S8。从光电探测器产生的光电电压对应于在导管探针的尖端处的两个LED(分别为645和950nm的峰值波长)的操作。 a.u., arbitrary units. (E) Measured photovoltage as a function of immersion time in PBS solution at 37°C. Experimental details appear in figs. S10 and S11. The data indicate negligible change in performance over 8 weeks. (F) CT image of the catheter sensor after 2 weeks of implantation. (G and H) Analysis of complete blood count (G) and blood chemistry (H) for mice with an oximetry probe implanted subcutaneously for 30 days (labeled as Experiment) and for mice without device implantation (labeled as Control). Credit: Science Advances, doi: 10.1126/sciadv.abe0579
引文:无线,可植入的导管型血氧仪,专为心脏氧饱和度(2021,2月25日)从HTTPS://medicalXpress.com/news/2021-02-vireless-implantable-catheter-cardiac of Https://medicalicalxpress.com-无用。HTML.
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