图3A:露天测试结果当一只老鼠被放在一个盒子里时，它会开始调查它所处的环境。老鼠在新环境中通常喜欢角落，避开中心的开放区域。通过计算在每个区域花费的时间和移动的距离，就有可能评估老鼠的焦虑程度。到目前为止，本研究中使用的15q dup小鼠在实验中表现出高度焦虑。B:社会互动测试的结果。两只从未见过面的老鼠被放在同一个盒子里。社交性是通过观察他们互动和身体接触所需的时间来评估的。在研究小组迄今为止的研究中，15q dup小鼠在该测试中的社交能力低于正常小鼠。C:使用巴恩斯迷宫进行逆向学习测试的结果:巴恩斯迷宫是一个有12个洞的圆板，其中只有一个洞是“目标”。 The target hole has a box below it that the mouse can enter. A bright light is positioned above the circular plate. Mice generally dislike bright light and prefer dark places, so if a mouse is put on the plate, it will look for somewhere to hide. Using this characteristic, the mouse can be made to learn the target hole’s location over a period of days (C, upper illustration). Once the mouse has learned the target’s location correctly, the target’s location is reversed and relearned (C, lower illustration). It is understood that normal mice learn the new target location comparatively quickly compared to 15q dup mice who are slow to learn the new target, and persist in going to the original target’s location (perseveration). For the learning test, the target is removed and learning is evaluated by observing which hole(s) the mouse goes to and how long it stays there (Figure 3- right: TA= the new target hole and the two holes on either side. AJ1, AJ2: The three holes in each adjacent sector, OP: The previously learned target, and the two holes on either side.). Credit: Kobe University
