Do pain relievers impede bone drug's efficacy?

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New research published in theJournal of Bone and Mineral Researchsuggests that non-steroidal anti-inflammatory drugs (NSAIDs) that are taken to reduce pain may block the beneficial effects of bone-protective drugs called bisphosphonates.

In the study of 5,212 community-dwellingaged 75 years and older, the use of NSAIDs did not seem to have a direct impact on individuals' bone fracture risk, but the medications appeared to negate the bone-protective effects of the oral bisphosphonate, clodronate, on preventing osteoporotic fractures.

"We need to exercise some caution in extrapolating these data to more widely used bisphosphonates in, but given that concomitant usage of NSAIDs and bisphosphonates is relatively common, this could have major clinical consequences and result in a failure to reduce fracture risk as much as we had hoped," said senior author Eugene McCloskey, MD, of Northern General Hospital, in the UK.

More information:Potential adverse effect of non-steroidal anti-inflammatory drugs (NSAIDs) on bisphosphonate efficacy. An exploratory analysis from a randomized controlled trial of clodronate.,Journal of Bone and Mineral Research(2022).DOI: 10.1002/jbmr.4548

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Citation: Do pain relievers impede bone drug's efficacy? (2022, April 20) retrieved 29 April 2023 from //www.puressens.com/news/2022-04-pain-relievers-impede-bone-drug.html
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