血清-突触核蛋白和血浆pta181的组比较、相关性分析和诊断性能。(A)比较无神经疾病(HC, n = 23)的整倍体健康对照和诊断为阿尔茨海默病(有症状,sDS, n = 14)或无AD(无症状,AD, n = 47)的唐氏综合征(DS)成人的血清β -突触核蛋白和(B)血浆pta181水平。以年龄和性别为协变量,对各组进行生物标志物水平log2转换后的多元线性回归比较。方框是中位数和四分位范围;须值为最小值和最大值。****p < 0.0001。(C)血清β -突触核蛋白和(D)血浆pta181水平随年龄变化的散点图。采用线性(HC)和二阶多项式回归(DS)来估计实线指示的生物标志物变化的时间过程(95%置信区间[CI])。虚线表示两条回归线分叉的年龄(95% ci不再重叠的点)。点和三角形是单独的值。 (E, F) Receiver operating characteristic curve analysis of (E) beta-synuclein and (F) pTau181 levels for discrimination of the different groups. Beta-synuclein: HC vs sDS, area under the curve (AUC) = 0.99, 95% CI = 0.98–1.00; aDS vs sDS, AUC = 0.94, 95% CI = 0.85–1.00; HC vs aDS, AUC = 0.90, 95% CI = 0.81–0.99. pTau181: HC vs sDS, AUC = 0.97, 95% CI = 0.92–1.00; aDS vs sDS, AUC = 0.95, 95% CI = 0.90–1.00; HC vs aDS, AUC = 0.55, 95% CI = 0.40–0.70. (G, H) Spearman partial correlation analysis of (G) beta-synuclein and (H) pTau181 levels with achieved number of points relative to the number that could maximally be reached on the Cambridge Cognitive Examination for Older Adults with Down Syndrome (CAMCOG-DS), including age as covariate. Beta-synuclein: aDS, r = 0.15; sDS, r = −0.75. pTau181: aDS, r = 0.04; sDS, r = −0.69. Dots are individual values, and lines are from linear regression. Credit:神经病学年鉴(2022)。DOI: 10.1002 / ana.26360