简单的血液测试可以使口腔癌的早期检测
![Diagram of the serum metabolic profiling workflow by CPSI-MS/ML. (a) Two cohorts of serum samples were collected from the OSCC and HC volunteers as the marker discovery and validation sets, respectively. (b) One drop of dried serum spot (3 μL) was loaded onto a conductive polymer tip. Once the extraction solvent was spiked, the high voltage was switched on to trigger the data acquisition. (c) The high-dimension metabolic profiles of different groups were classified and visualized under the constructed 3D features space by an unsupervised machine learning model; (d) From a statistical analysis, the discriminating metabolites were selected as features. (e) Given the data of the two cohorts as the training and test sets, a machine learning model was applied; (f) The serum metabolite markers were further validated at the tissue level and the combination was employed as the diagnostic panel. tSNE, t-distributed stochastic neighbor embedding; Ln(FDR), natural logarithm of false discovery rate; Lv, latent variable. Credit: Natural Sciences (2021). DOI: 10.1002/ntls.20210071 简单的血液测试可以使口腔癌的早期检测](https://scx1.b-cdn.net/csz/news/800a/2022/simple-blood-test-may.jpg)
当前60%的五年存活率与口腔鳞状细胞癌(OSCC)——个人类型的癌症的嘴和throat-could大大提高如果尽早开始治疗。 发表的一项研究中自然科学,研究人员使用一种导电聚合物喷雾电离质谱技术筛选血液代谢OSCC的迹象。该方法可以准确区分个人和没有OSCC
两个改变脂质标记,发现血液中可以追溯到癌症网站指导外科评估。
该方法只需要一滴血液会还区分患者的早期和后期OSCC
“这项研究代表了水果的研究包括美国和中国,在其中所有的参与者相信,结果将是一个赢得对两国和世界作为一个整体,一个想法,似乎唉消失在这些时期国际合作的相互猜疑和不信任,“说共同通讯作者理查德·N Zare,斯坦福大学的博士。
一篇研究的作者强调指出,这项研究“是一个完美的展示方式质谱分析基于代谢组学的工作流可以简化,使它们在临床应用可用。”
更多信息:西湖杨et al,大组的血清代谢组学分析口腔鳞状细胞癌筛查和诊断,自然科学(2021)。DOI: 10.1002 / ntls.20210071
所提供的威利
引用:简单的血液检测可以早期发现口腔癌(2022年6月7日)2023年5月17日从//www.puressens.com/news/2022-06-simple-blood-early-oral-cancer.html检索
本文档版权。除了任何公平交易私人学习或研究的目的,没有书面许可,不得部分复制。内容只提供信息的目的。