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class="article__info mb-2"> <div class="article__info-item mr-auto"> <a href="//www.puressens.com/archive/12-07-2022/" rel="nofollow"> <svg class="article__info-icon"> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_clock" x="0" y="0"></use> </svg></a> <p class="text-uppercase text-low">2022年7月12日< /p> </div> </div> <h1 class="text-extra-large line-low mb-2">研究显示试验药物促进损伤后神经修复< /h1> <p class="article-byline text-low">通过<a class="article-byline__link" href="http://www.bham.ac.uk/" target="_blank">伯明翰大学< /a></p> <div class="mt-4 article-main"> <div class="article-gallery lightGallery"> <div data-thumb="https://scx1.b-cdn.net/csz/news/tmb/2021/spine.jpg" data-src="https://scx2.b-cdn.net/gfx/news/hires/2021/spine.jpg" data-sub-html="Credit: Unsplash/CC0 Public Domain"> <figure class="article-img"> <img src="https://scx1.b-cdn.net/csz/news/800a/2021/spine.jpg" alt="脊柱" title="Credit: Unsplash/CC0 Public Domain" width="800" height="530"> <figcaption class="text-darken text-low-up text-truncate-js text-truncate mt-3"> 信贷:Unsplash / CC0公共领域< /figcaption> </figure> </div> </div> <p>伯明翰大学的科学家已经证明,一个brain-penetrating候选药物目前在开发癌症治疗可以促进受损脊髓创伤后神经的再生。< /p> <div class="w-100 my-4 d-print-none"> <ins class="adsbygoogle" style="display:block; text-align:center;" data-ad-layout="in-article" data-ad-format="fluid" data-ad-client="ca-pub-0536483524803400" data-ad-slot="7587637799"></ins> </div> <p>的<a href="//www.puressens.com/tags/research/" rel="tag" class="textTag">研究< /a>今天发表在<i>临床和转化医学< /i>时,用细胞和动物模型证明口服候选药物,被称为<a href="https://openinnovation.astrazeneca.com/preclinical-research/preclinical-molecules/azd1390.html">AZD1390< /a>,可以阻止响应DNA损伤<a href="//www.puressens.com/tags/nerve+cells/" rel="tag" class="textTag">神经细胞< /a>和促进<a href="//www.puressens.com/tags/regeneration/" rel="tag" class="textTag">再生< /a>受损的神经,所以恢复感觉<a href="//www.puressens.com/tags/motor+function/" rel="tag" class="textTag">运动机能< /a>后<a href="//www.puressens.com/tags/spinal+injury/" rel="tag" class="textTag">脊髓损伤< /a>。< /p> <p>几周前宣布同一个研究小组显示<a https: www.puressens.com news 2022-05-spinal-cord-injury-treatment.html">不同的试验药物< /a>(AZD1236)可以减少损伤后脊髓损伤,通过阻断炎症反应。这两项研究是由阿斯利康的开放创新计划,股票的化合物,与科学界的工具、技术和专业知识,促进药物发现和开发。< /p> <p>AZD1390还在调查中,阿斯利康块ATM-dependent信号和修复DNA双链断裂(双边带),一个动作,糖分会让癌症<a href="//www.puressens.com/tags/cells/" rel="tag" class="textTag">细胞< /a>放射治疗。DNA损伤反应系统(DDR)是由DNA损伤激活,包括基因组中双边带,这发生在几种常见肿瘤,脊髓损伤后也。< /p> <p>Zubair艾哈迈德教授大学研究所的炎症和衰老和癌症研究所的Richard Tuxworth博士和基因组科学假设的持续激活这个系统可以防止恢复脊髓损伤,阻止它将促进损伤后神经修复和恢复功能。< /p> <p>他们的初步研究发现AZD1390刺激神经细胞生长在文化、和抑制了ATM蛋白激酶路径a关键生化途径调节响应DNA损伤。< /p> <p>研究人员然后用动物模型研究后AZD1390脊髓损伤的影响。他们表明,口服治疗AZD1390导致显著抑制的ATM蛋白激酶通路,神经再生网站之外的损伤,这些神经电信号的能力的损伤。< /p> <p>艾哈迈德教授说:“这是一个激动人心的时刻在脊髓损伤研究和几个不同的试验性药物被认为是潜在的治疗脊髓损伤。我们特别兴奋AZD1390可以口服和受伤的网站能在足够的数量来促进神经再生和恢复失去的机能。< /p> <p>“我们的发现显示出非凡的感觉和运动功能的恢复,和AZD1390-treated动物区别受伤动物受伤的4周内。”< /p> <p>Tuxworth博士补充说:“这早期的研究表明,AZD1390可以作为治疗改变生活条件。此外,再利用这现有的试验性药物可能意味着我们可以达到临床显著高于从头开始开发一种新药。”< /p> <p>伯明翰大学企业提起专利申请涉及ATM /相关的DNA损伤反应的抑制途径AZD1390等化合物,这可能代表一个潜在的治疗策略,促进神经修复。< /p> <hr> <div class="article-main__explore my-4 d-print-none"> <div class="d-flex align-items-center"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#plus" x="0" y="0"></use> </svg> <p class="text-bold mb-0 ml-2">进一步探索< /p> </div> <a class="text-medium text-info mt-2 d-inline-block" href="//www.puressens.com/news/2022-05-spinal-cord-injury-treatment.html">研究对脊髓损伤的治疗带来了希望< /a> </div> <hr class="mb-4"> <div class="article-main__more p-4"> <strong>更多信息:< /strong>艾哈迈德·Z Tuxworth RI。大脑渗透ATM抑制剂,AZD1390,促进轴突再生和功能恢复的临床前模型脊髓损伤。<i>临床和转化医学< /i>(2022)。<a data-doi="1" href="https://dx.doi.org/10.1002/ctm2.962" target="_blank">DOI: 10.1002 / ctm2.962< /a> </div> <div class="d-inline-block text-medium my-4"> 所提供的<a href="//www.puressens.com/partners/university-of-birmingham/">伯明翰大学< /a> <a class="icon_open" href="http://www.bham.ac.uk/" target="_blank" rel="nofollow"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_open" x="0" y="0"></use> </svg></a> </div>  <div class="d-none d-print-block"> <div class="mb-4"> <strong>引用< /strong>:研究显示试验药物促进损伤后神经修复(2022年7月12日)检索3 2022年9月从//www.puressens.com/news/2022-07-drug-fosters-nerve-injury.html< /div> <div class="border text-muted p-3"> 本文档版权。除了任何公平交易私人学习或研究的目的,没有书面许可,不得部分复制。内容只提供信息的目的。< /div> </div> </div> </article> <div class="article-interaction my-4 d-flex align-items-center d-print-none"> <a href="javascript:void(0)" class="btn btn-info px-4 py-2 text-regular border-0 mr-4"><span>2019年< /span>股票< /a> <ul class="ml-md-auto ml-sm-0 article-interaction__social d-flex"> <li><a href="javascript:void(0)" class="article-interaction__link fb"> <svg> <use href="https://medx.b-cdn.net/tmpl/v6/img/svg/sprite.svg#icon_fb_news" x="0" y="0"></use> </svg><p class="text-regular mb-0">脸谱网< /p></a></li> <li><a href="#" class="article-interaction__link tw" data-title="Research shows investigational drug 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