BC省HDAC6得分。(a)用于评估HDAC6规则的样本数量和原始数据集。(b)原始和更新的HDAC6规则重叠。使用双尾Fisher精确检验估计P值。N由网络推理的基因总数确定。(c) HDAC6的网络图和更新后的HDAC6规则。边宽对应互信息测量的相关强度。红色和蓝色边表示HDAC6和每个调控基因之间的正相关和负相关。下表显示了该调控基因的通路富集情况，显示了其与未折叠蛋白反应的关系。使用双尾Fisher精确检验估计P值。 (d) New HDAC6 score comparing IBCs vs non-IBCs. (e) HDAC6 scores of all BCs from TCGA and METABRIC are divided into molecular subtypes. (f) HDAC6 scores in 45 ductal metastatic breast cancer samples from the MBC Project divided into histological molecular subtypes. In d, e and f, the center line indicates the median value. The lower and upper hinges represent the 25th and 75th percentiles, respectively, and whiskers denote 1.5x interquartile range; the red line represents the median of the HDAC6 scores in IBC samples and the numbers over each whisker plot indicate the percentage of samples over this value in each clinical subtype. Sample size (n = number of samples) of each group was indicated in the axis labels. P value was estimated using two-tailed t test. Credit:自然癌症(2022)。DOI: 10.1038 / s43018 - 022 - 00489 - 5
