Gender and age differences found in gene expression related to circadian clock

一个trio of bioengineering scientists at Ecole Polytechnique Fédérale de Lausanne has found age and gender differences in gene expression related to the circadian clock. For their paper published in the journalScience, Lorenzo Talamanca, Cédric Gobet and Felix Naef analyzed data obtained for the Genotype-Tissue Expression project.

Prior research has shown that rhythmic changes occur ingene expressiondue to the circadian clock, particularly during the morning and evening hours. But as the researchers in this new effort note, not much study has been done regarding differences in circadian gene expression due to gender or age.

To find out if such differences exist, the trio analyzed data obtained for the Genotype-Tissue Expression project. They filtered down donors in the database to just 914 and used their RNA data profiles as input for an algorithm that assigns a circadian phase to a given sample of tissue. This allowed them to note the level of material present, such as protein, that had been genetically expressed. Different levels showed different expression levels during different parts of the circadian cycle—testing was done on 46 tissue samples.

In looking at the sources of thetissue samples, the researchers observed differences between tissue types and between male and female donors and also between younger and older donors. More specifically, they found that gene expression related to metabolism was more rhythmic compared to other body tissue and that brain tissue was less. They also found more rhythmicity in women compared to men and more inyoung peoplethan in older people.

The researchers noted thatgender differenceswere much higher than expected—the number of rhythmic genes in women was roughly double that in men. And it varied bybody parts—women showed more rhythmicity in gene expression in the liver and adrenal gland. They also found variances by body part related to age—older people, for example, had less rhythmicity in genes related to coronary arteries and the cardiovascular system in general. They also found that thecircadian clocktended to shift from 24 hours to 12 as people reached a certain age.

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