本文综述了科学根据XgydF4y2Ba编辑过程gydF4y2Ba和gydF4y2Ba政策gydF4y2Ba。gydF4y2Ba编辑器gydF4y2Ba强调了以下属性同时确保内容的可信度:gydF4y2Ba
核查事实的gydF4y2Ba
同行评议的出版物gydF4y2Ba
可信的源gydF4y2Ba
校对gydF4y2Ba
“双眼”治疗之后,睡眠帮助发现常见的视力问题gydF4y2Ba
![BR is more effective than RO at reversing MD-induced ocular dominance shifts. a Experimental design. Mice underwent 5-day MD from P28-P33. MD mice were recorded at P33. Two recovery groups with either binocular recovery (BR) or reverse occlusion (RO) visual experience from P33-38 had daily 4-h periods of visual enrichment starting at lights on and were recorded at P38. Normally-reared (NR) mice were recorded at P38 without prior manipulation of vision. b Representative image of electrode probe placement in binocular primary visual cortex (bV1) coronal section stained with DAPI and enlarged view of electrode contacts, which spanned the layers of bV1 (scale bar = 200 µm). Schematic of bV1 coordinates in coronal sections where green lines represent probe placements in bV1 for all groups. c Ocular dominance histograms from bV1 neurons recorded contralateral to the original DE for all four groups, using a 7-point scale (1 = neurons driven exclusively by contralateral eye; 7 = neurons driven exclusively by ipsilateral eye, 4 = neurons with binocular responses) n = 5 mice/group. d Cumulative distribution of ocular dominance indices for all neurons recorded in each group. e Contralateral bias indices for mice in each treatment group. One-way ANOVA: F (3, 16) = 29.34, p < 0.0001. Error bars indicate mean ± SEM. f The proportion of recorded neurons classified as regular spiking (RS) neurons and fast-spiking (FS) interneurons in each treatment group. RS neurons: NR (n = 175); MD (n = 192); BR (n = 196); RO (n = 175). FS interneurons: NR (n = 47); MD (n = 46); BR (n = 34); RO (n = 42). g, h Ocular dominance index cumulative distributions for RS neurons (g) and FS interneurons (h). Ocular dominance index values for both populations were significantly shifted in favor of the SE after MD, were comparable to those of NR mice after BR, and were intermediate—between NR and MD values—after RO. **, ***, and **** (gray) indicate p < 0.05, p < 0.01 and p < 0.0001, K–S test vs. NR (d, g, h) or Tukey’s post hoc test vs. NR (e); #, ### and #### (orange) indicate p < 0.05, p < 0.001 and p < 0.0001, K-S test vs MD (d, g, h) or Tukey’s post hoc test vs MD (e); ns indicates not significant. Credit: Communications Biology (2023). DOI: 10.1038/s42003-023-04798-y “双眼”治疗有助于一个常见的视力问题。睡眠使它。gydF4y2Ba](https://scx1.b-cdn.net/csz/news/800a/2023/binocular-treatment-he.jpg)
弱视,有时被称为弱视,是一种常见的视力问题儿童和婴儿,这是典型的治疗,让孩子穿补丁强眼,与较弱的眼睛视力改善的目标。gydF4y2Ba
最近的研究表明,治疗需要两只眼睛一起工作可能会帮助那些gydF4y2Ba弱视gydF4y2Ba恢复得更好。其他研究已经表明,适当时机gydF4y2Ba睡眠gydF4y2Ba可以帮助gydF4y2Ba神经网络gydF4y2Ba在gydF4y2Ba大脑修复gydF4y2Ba或重组,特别是孩子,密歇根大学的研究员萨拉阿托恩说。gydF4y2Ba
阿托恩的实验室在音乐会,看了看两个研究问题,发现视觉刺激了双眼,而不是仅较弱的眼睛,帮助老鼠弱视经验更视觉功能的完全恢复。甚至更好的结果,老鼠可以睡在他们的丰富gydF4y2Ba视觉体验gydF4y2Ba。团队的研究结果发表在《华尔街日报》gydF4y2Ba通信生物学gydF4y2Ba。gydF4y2Ba
“目前的标准实践治疗儿童甚至成年人,与弱视可能有改进的余地,”阿托恩说,副教授的分子、细胞和发育生物学”。First, our findings suggest that patching therapy, which has been used routinely for several decades, may be inferior to more recently developed methods aimed at making the eyes work together.
“第二,它表明,关注儿童睡眠的时间关于这个治疗,很容易实现的东西,可能会有巨大的好处关于治疗的潜力。”gydF4y2Ba
检查弱视,研究人员检测了小鼠相同类型的长期损失发生在大脑的视觉信息处理儿童弱视。然后提出了丰富gydF4y2Ba视觉刺激gydF4y2Ba——类似于人类老鼠的电影。老鼠也有更强的眼睛关闭,模仿修补治疗,或被允许保留同时睁开双眼。gydF4y2Ba
研究人员发现,双目视觉stimulation-seeing与双眼总共造成更大的大脑可塑性。更重要的是,他们测试了睡眠的重要性这个疗法。当老鼠被允许睡觉,但他们的睡眠中断后的最初几个小时的视觉刺激,这些福利是逆转。gydF4y2Ba
他们的发现表明,修补治疗,常用几十年来,可能不如最近开发的方法旨在使眼睛一起工作。工作也表明,关注儿童睡眠的时间关于这个治疗,很容易实现的东西,可能会有巨大的好处关于治疗的潜力。gydF4y2Ba
“我希望这将开辟新的途径为临床医师尝试与他们的儿科患者。弱视会影响一大片的人口,介于1%和6%的所有人,”阿托恩说。“修补治疗gydF4y2Ba标准治疗gydF4y2Ba几十年来,但它最初开发,部分基于老,动力不足的研究。gydF4y2Ba
“我们的技术能力视觉治疗改善了自那以后,就像我们理解的睡眠有助于大脑功能发展。所以希望与新数据我们将看到新的数据驱动的对孩子的治疗方案。”gydF4y2Ba
更多信息:gydF4y2Ba杰西·马丁内斯et al,丰富双目经验其次是睡眠最佳恢复双目视觉皮层反应弱视的小鼠模型,gydF4y2Ba通信生物学gydF4y2Ba(2023)。gydF4y2BaDOI: 10.1038 / s42003 - 023 - 04798 - ygydF4y2Ba