男朋友中断妥协身体小鼠的体重和肌肉功能。动物实验都是在WT和BVES-KO雄性小鼠C57BL / 6 n的遗传背景。免疫荧光图像的GA WT, BVES-KO老鼠的肌肉(4个月)与抗体对bf和DAPI染色。酒吧规模:100µm。每个基因型(n = 4)。b代表的形象WT BVES-KO男同窝出生4个月大的时候。c,身体体重的男性BVES-KO和年龄/ sex-matched WT从两到五个月大的老鼠。双尾配对t测试学生的。d kaplan meier WT和BVES-KO雄性小鼠的存活曲线。e自愿轮运行BVES-KO和年龄WT雄性老鼠(4个月)。 f, g Endurance capacity test performed by treadmill running showing running distance (f) and time to exhaustion (g) in BVES-KO (n = 5) and WT (n = 5) male mice (4 months of age). Two-tailed unpaired Student’s t test. h The number of dropouts to test the capacity of recovery from muscle injury on the treadmill in BVES-KO and WT male mice (6 months of age). Two-tailed paired Student’s t test. i Tetanic torque measurements of the posterior compartment muscles of BVES-KO and WT male mice in age-dependent manner (2-month age: WT (n = 11), BVES-KO (n = 9); 4-month age: WT (n = 9), BVES-KO (n = 9); 6-month age: WT (n = 9), BVES-KO (n = 8)). ns indicates no significant difference. Two-way ANONA with Tukey’s multiple comparisons test. Data are mean ± SEM. Source data are provided as a Source Data file. Credit:自然通讯(2023)。DOI: 10.1038 / s41467 - 023 - 37496 - 8
