%PDF-1.7 % 16 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20221011095625-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 17 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 6 0 R 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R ] /PZ 1 >> endobj 17 0 obj <> stream x\rF}Wt%vN1։Smbi7[a Yf~vυ)ڕ ɥ I>}9%s`>_?%~WMAn s;?xiEIs(ꋗJ^> |/Ky3o !ʛ>z8}Y JulHGK<ǁ)m >[oPL3hdrFɲ/:!q?Y`eY'?CEΠf{蛒JpoK3 ,7Jru~'׮_{I5^p_sb\Gy4d,W7eQKtL\Pp0aتM*^n! #/ = %%bouT5Zf%[ŷjԭ9,rU檅%{:i<22kF*x۴z\Ula)!C?,4вi-[_e3KٴCd& aK3 uGQ` ̡]9~!̒"r;BGix9pG֘Ne= }Q2 r) |P=ܓR$ jV4i f uv) E ;GPhW`0V aXcȍ&JCsÃYj5,6]p(/n7'ę!BȚ;̧k=2;`dl kaǫ ܰ_fُAw6h VXH: 4Y[b/g?0xpT =j# YY<LvHM䐑ImoHnY!9FP|D9:G8`=:1]\B$Oa|fE0$G:7?8ay\zwjFSwht£'\g#o[ٶ 6ڌOn#O#Oþ7B[#Vu~n&Ty1ZT>>yZ'g:ɛE>ú?Vurͪfd }@ߍW5D9kѵtEtO$_Ќp]p1kvӲZL=9 츮q tI,PgEwZS)NwjV6|NZy'9EqRX~?͐ q#H3hchyxVJ']ؕ-Ao:%8~I]O\J=g Ɉf oސw!#PrQ7 OTmIDW0i uDYeM!6 0P4՟ zW'Phk+]D~ݎ!>ǰt R6RG^0): .dV%֨󓉛#17 REێ)Itk$xz:Kp]3]\!N+pշ^l07}xXnщ"L,Y5@Sʐ PAyG)$3S*&;pjo"}3t ^ @u]*AɶLC[p;t8=9F:5%%IlYǹ.lK>(4"o gFp''J  j !!pS9h*xLDaY~뙾|#ASnK$>PJ$dzgUGV6N#{D郊.Gm8~f=9Sq?t}'s!IBoQ0<\͗~аq"?w֧x   endstream endobj 18 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20221011095625-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 19 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 13 0 R 14 0 R 15 0 R ] /PZ 1 >> endobj 19 0 obj <> stream xZr6+xdF9uNEg.  VԯHڲ-?$-2 {p\l#|+#i$sk^s,V{H`pq [ILIH#'G,"8=}w< YRhL"žHq<8cC}uumoWOhDh8E\0%W\\}5L)pUWX`|7-x.^F\pu˄yc(ź%o WP ^V4k˧1H.Lc!4gほw\`¹pN~.N5ĭ9/:ǒi [VRyɕsĬڈ5 |6BukL_L}f:dKBnXrVRP,ұGSZ=>Vi m2p+Lz)j6}QO(@( m RCUZ HXVReSbl@=$\˼jš”B$)z{Fd[ AV-%Ȱu#eO0p4v(lu2fLE]Z9L-"Ze#>Y^OunJn5cj_D}%>@jYIU;wxLNi MǛ-_8fۼL6?}Y@dh6Nx `qUunK-ߞ| dB)5*yx+§AP>{$.SetgiH|]me%t%J4K Aa.~:_%:1‘ϔ@SrtsV/,_}z.dG$?<>;\^iUKg3h$ [Pv5Eg`x\a(Z}&s{tlm砸Q}wSnxA+%[T×QTe$351~qtT[S$%bc3Rd}9qX=n=jvZH^rc}s~=.cN].p(wM;Lю+pfSj?/qr[ ;`wG"ۭ8n2}`VP ٽŕݬۦjX9[%.rG]q[jGuaHR uX)rl _r9bp7JX mW\6fvz {k䶗mӧ'# ICڧoLn۳WplŊH>~i_R=°}:fgGY|7~@"@ $q^[ϑ Y6*%GG0W?uk endstream endobj 1 0 obj << /Type /Pages /Kids [ 16 0 R 18 0 R ] /Count 2 >> endobj 3 0 obj <> endobj 5 0 obj <> endobj 12 0 obj <> endobj 20 0 obj <> stream JFIFHHExifMM* z(1>?QQ Q HHPaint.NET v3.5.10z%u0`:oCC." }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?(f 1T$`9Sw(B@;~(]Cd꾫Es:aݻd2\(2F][&]ۢϲ|W͵L@A A 8 (CĝCglZE/ |Ezє{ xQʒ@[ྊ\/I4R0?6.7`ŴwPu|3/Z@Ogi}cFdFKoj?~8|p_A<ĺOkGPK $wRmkmF;YVx&rLj#p ׭axf|s$Ӿc:Qwm]N)Cψ[eYba98xB+oTÚwcRþ$U[ ?qΙ{&jv6Xo$=ԗ&7zgAxIִ.$3,mwc{+%g[!U@&Fϻm/#hci'7n[%It.&/ֶ+Zl~:wi~D>$}o+}@.[/+B6mnt8bi{zc.~F{eUe86g3 VT&> BK VؘXzSMesoM_&ϔIÍK?+hڿnt_ K]H '̽yrWA=O+|"!gɤItXe>Xs hwwG Eouqa /ş_~~'x} ]_^]/ 蚼:<cu/ h&omEۯicǪ\[,k}_uS}㏆W]G^tmf`Ks ]=va&h9n忔>75NWQτ0of,E (˰8hBC_ Jq'W UQKz,N>+`S%}b5ISJ]+(&QVN>eoy7xG4[]]3K{i$I>g-(mbynLIC,"*3f?-%`lfPx涽X"H'h"ֈ(TfeU:܉,a,R*I4xcxalOhGр|ia$cg,{gAHEu->]F,{-.,EX"I$XQD/3R.{{T&ҭ%4[OPnx"HhM :e}-Լ'=s:\iZ<+Lj5+1AɮLZx-☽G3 1I"kuχ+A}5'NxI8 gJk[oenm!x,=n=>}kjPx~M񧍼5k45a,RLiȖTFQMR&K;}r+XkY[y>2F=2~6>Gmi++<[WF76MH4>;;Kf۽ъM3ZE}c㿈*- -.|G5uI![ YR$$A>Eyׇ|7u;n>4׭JϷR[h!rVr\{~Ϛ >0jMg?_y_ Do/x;ÚƏi a𶕦f|Eqgk4V^RY]}F,/J%ՌAud%:x3Hg_4[+^ ҴKaXF'n.]Z(i$bef5GO:u]/a~.3N4xiG*a8ާ-U){G nJEڿ[m7wv5MYp|'gm # #%B?|鿲w­{+_|Q#VkxcZޛ{I]Wyak}..i˨iY9QwOA~hf{+ |Y;cڴ27G>|H,na8o; CEO,ZLP?SHK} e92W7/1aj¤aڄq4 қS7,5]%EƔc/uҒw\r/EnT y>!V+VK4X^Y{;+Ӫ=MqslEn?Zz'Ë}^2xĺGf70/M~*DU=坍G{wwvci%vZ$GY&J9dkՀ\6hs.F*ĩ"+S%s*{ qqDj3$ q^T24,Cn +=j񟍼q5k'\%ݎ{ͦuyq4X$y<ك2Ey%™|Icw]3#R[`{KցY [1*kLOdw ^OAkЏb<¿ <=6x0ׄ>(=*[ t]9-?IZ@}/>FۃQ@ endstream endobj 4 0 obj << /Type /XObject /Subtype /Form /FormType 1 /Filter /FlateDecode /BBox [0.000000 0.000000 595.276000 76.535433] /Matrix [1 0 0 1 0 0] /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F2 5 0 R /F1 3 0 R >> /XObject << /I0 20 0 R >> >> /Length 197 >> stream xKkBA WeI&ڊU/ nʥBf8A3!(X4`JQj*Aj͕197f hkL[=µrw]F D%x2WC0 9)Z ^Wh}29yyu?4g=bT1߻a endstream endobj 2 0 obj << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F1 3 0 R /F2 5 0 R /F3 12 0 R >> /XObject << /XT4 4 0 R /I0 20 0 R >> >> endobj 6 0 obj <> /H /I>> endobj 7 0 obj <> /H /I>> endobj 8 0 obj <> /H /I>> endobj 9 0 obj <> /H /I>> endobj 10 0 obj <> /H /I>> endobj 11 0 obj <> /H /I>> endobj 13 0 obj <> /H /I>> endobj 14 0 obj <> /H /I>> endobj 15 0 obj <> /H /I>> endobj 21 0 obj << /Title (Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease) /Subject (Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease) /Creator (Science X Network) /Producer (TCPDF 6.3.5 \(http://www.tcpdf.org\)) /CreationDate (D:20221011095625-04'00') /ModDate (D:20221011095625-04'00') /Trapped /False >> endobj 22 0 obj << /Type /Metadata /Subtype /XML /Length 4837 >> stream application/pdf Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease Impaired clearance, not overproduction of toxic proteins, may underlie Alzheimer's disease 2022-10-11T09:56:25-04:00 Science X Network 2022-10-11T09:56:25-04:00 2022-10-11T09:56:25-04:00 TCPDF 6.3.5 (http://www.tcpdf.org) uuid:ea584988-7546-9a8a-f762-65eed330bcae uuid:ea584988-7546-9a8a-f762-65eed330bcae http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal Adobe PDF Schema InstanceID URI http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text endstream endobj 23 0 obj << /Type /Catalog /Version /1.7 /Pages 1 0 R /Names << >> /ViewerPreferences << /Direction /L2R >> /PageLayout /SinglePage /PageMode /UseNone /OpenAction [16 0 R /FitH null] /Metadata 22 0 R >> endobj xref 0 24 0000000000 65535 f 0000005865 00000 n 0000012401 00000 n 0000005932 00000 n 0000011900 00000 n 0000006038 00000 n 0000012548 00000 n 0000012789 00000 n 0000013036 00000 n 0000013280 00000 n 0000013533 00000 n 0000013785 00000 n 0000006149 00000 n 0000014041 00000 n 0000014338 00000 n 0000014634 00000 n 0000000015 00000 n 0000000517 00000 n 0000003530 00000 n 0000004015 00000 n 0000006264 00000 n 0000014852 00000 n 0000015484 00000 n 0000020404 00000 n trailer << /Size 24 /Root 23 0 R /Info 21 0 R /ID [ ] >> startxref 20614 %%EOF