%PDF-1.7 % 16 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20220812150726-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 17 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 7 0 R 8 0 R 9 0 R 10 0 R 11 0 R 12 0 R ] /PZ 1 >> endobj 17 0 obj <> stream x\ms6_߮aoI]/MܗhА_ (؎Q=˴]>X#< ~g//_O .؁i;xq($dů ~G?GЏ^A>I}}O#پ [mh2p1QYhewo߽UJ&+d5/^}OATnJjpTAT@*U-ERRȥ,_ПCo]262 Fx2ML} ?kQ^ GS ADa 3$fD(LJ_'lFC}ENwx@6to<@]MXLh$(7r_IyO6#P:ǸiM I,[c>7ӗQb̒$LKce0A%toT( x)U(o`Bڠ kNۧ7>4}gAG&x'jZ2R+ļlLAeM٠JO^, H8Xs6 U*B Q}xF: Ŕ5V"6hjMsET3!-H˩a1I مr<5aBIDBzxY׫ ɕ$J/.G0dW*K؟ i!.8G $}J y̌F(Ƭ^2]=\S硽E/tHXdfҹňa6< Id;_5WjQUQ]9Fe_/m+' $3bLr*"Һhhb;QwQypnd;]!hd|s1swӽ$aH #SIMɇ* mC1+X?6 {+(EUHsK I@F >@Ь@Fh;J+HG䩡- .-77啐^4vF4cvLߨg YbgK_ʈOߴQ;wl=7":H_)\QpEתXH[IuZ7*wŮ"5 ?tl1蒌 V-:mX/jA]KFYUGm2S7E!N1Lj)S~RX(&pTdMάl' 9ƊbNx2# WihXX##$VkoD8K:HWtZM N JxV;bݍ:J^eEJQ#))Fά0ޥ!}kY/IƎ°;t \*K\ 0L$QKsOJӁ,Ӵ] - _Du s/,>0 qd7颱VXnD+V =L8HZ2-LWѭvL MUi6K\Mڜb!*2-\OD4b5YՈpb=0zv44m>~伐7n,WN;F-JP)e6l&[Šٷ2v:t`ȿ+m#EQ plՕ ^<wK\R%Jܠ lD)ؓ["3dL!!Xt=>>B6ָ'XxtRDIޠDI;f̏q*>&moq^/l+ wEQҸ4pBK-ul8ޫ79:,K 3ֶƀθ'+4̮pdяHmiY'. }װ?q6aR(PebPU^ntz\&:[ mŚr8 ]z AK 6F &[Ѕ/`ػ;u906-p%沔'aE&n=Ξ{np6,؝==Uԅ$9ҝ=أMq26v2I6jڶeoAv>& 9ٝ:ّWI<șm>I (4vmǀ˭9(kaHk7%ȄČO;?b}~46#a<0Ȑ^.K6Єk#$<-/ ,/<r endstream endobj 18 0 obj << /Type /Page /Parent 1 0 R /LastModified (D:20220812150726-04'00') /Resources 2 0 R /MediaBox [0.000000 0.000000 595.276000 841.890000] /CropBox [0.000000 0.000000 595.276000 841.890000] /BleedBox [0.000000 0.000000 595.276000 841.890000] /TrimBox [0.000000 0.000000 595.276000 841.890000] /ArtBox [0.000000 0.000000 595.276000 841.890000] /Contents 19 0 R /Rotate 0 /Group << /Type /Group /S /Transparency /CS /DeviceRGB >> /Annots [ 13 0 R 14 0 R 15 0 R ] /PZ 1 >> endobj 19 0 obj <> stream xVMS0W0CI-|uC>t88-#˸wc !´Jhdi( P8./J|{B3&g #m4KSCvE+ϕđByo+p{kvK N$ \_ĥBzHF w\סH7FOW]vO9f%ncq>ȇ'+].C3LpAFY<͊ 1 O~+u=M4:Vpz,WKIVRp)cMߩ| pv ܓ+)cX )AGQdN%`0'ueSa-p/怽8D::Rkp0UwiTUXB5`~}2eGQXgƑ@#zy`kot%G(BhhH|$g%RAj)uv]6D[*#N =ѝDfY:sUX~UnTljrfIj .b(31*M)5*jeiu2VIQM@P=A B`Qؚ̦-d֪Je򬪰ӹ ے_.3xC]FZ"Ѝ2hidL<-78.}?ϗk\L=ʥ.^ )9iw!D% 09j)QʲP endstream endobj 1 0 obj << /Type /Pages /Kids [ 16 0 R 18 0 R ] /Count 2 >> endobj 3 0 obj <> endobj 5 0 obj <> endobj 6 0 obj <> endobj 20 0 obj <> stream JFIFHHExifMM* z(1>?QQ Q HHPaint.NET v3.5.10z%u0`:oCC." }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?(f 1T$`9Sw(B@;~(]Cd꾫Es:aݻd2\(2F][&]ۢϲ|W͵L@A A 8 (CĝCglZE/ |Ezє{ xQʒ@[ྊ\/I4R0?6.7`ŴwPu|3/Z@Ogi}cFdFKoj?~8|p_A<ĺOkGPK $wRmkmF;YVx&rLj#p ׭axf|s$Ӿc:Qwm]N)Cψ[eYba98xB+oTÚwcRþ$U[ ?qΙ{&jv6Xo$=ԗ&7zgAxIִ.$3,mwc{+%g[!U@&Fϻm/#hci'7n[%It.&/ֶ+Zl~:wi~D>$}o+}@.[/+B6mnt8bi{zc.~F{eUe86g3 VT&> BK VؘXzSMesoM_&ϔIÍK?+hڿnt_ K]H '̽yrWA=O+|"!gɤItXe>Xs hwwG Eouqa /ş_~~'x} ]_^]/ 蚼:<cu/ h&omEۯicǪ\[,k}_uS}㏆W]G^tmf`Ks ]=va&h9n忔>75NWQτ0of,E (˰8hBC_ Jq'W UQKz,N>+`S%}b5ISJ]+(&QVN>eoy7xG4[]]3K{i$I>g-(mbynLIC,"*3f?-%`lfPx涽X"H'h"ֈ(TfeU:܉,a,R*I4xcxalOhGр|ia$cg,{gAHEu->]F,{-.,EX"I$XQD/3R.{{T&ҭ%4[OPnx"HhM :e}-Լ'=s:\iZ<+Lj5+1AɮLZx-☽G3 1I"kuχ+A}5'NxI8 gJk[oenm!x,=n=>}kjPx~M񧍼5k45a,RLiȖTFQMR&K;}r+XkY[y>2F=2~6>Gmi++<[WF76MH4>;;Kf۽ъM3ZE}c㿈*- -.|G5uI![ YR$$A>Eyׇ|7u;n>4׭JϷR[h!rVr\{~Ϛ >0jMg?_y_ Do/x;ÚƏi a𶕦f|Eqgk4V^RY]}F,/J%ՌAud%:x3Hg_4[+^ ҴKaXF'n.]Z(i$bef5GO:u]/a~.3N4xiG*a8ާ-U){G nJEڿ[m7wv5MYp|'gm # #%B?|鿲w­{+_|Q#VkxcZޛ{I]Wyak}..i˨iY9QwOA~hf{+ |Y;cڴ27G>|H,na8o; CEO,ZLP?SHK} e92W7/1aj¤aڄq4 қS7,5]%EƔc/uҒw\r/EnT y>!V+VK4X^Y{;+Ӫ=MqslEn?Zz'Ë}^2xĺGf70/M~*DU=坍G{wwvci%vZ$GY&J9dkՀ\6hs.F*ĩ"+S%s*{ qqDj3$ q^T24,Cn +=j񟍼q5k'\%ݎ{ͦuyq4X$y<ك2Ey%™|Icw]3#R[`{KցY [1*kLOdw ^OAkЏb<¿ <=6x0ׄ>(=*[ t]9-?IZ@}/>FۃQ@ endstream endobj 21 0 obj <> stream JFIFC    $.' ",#(7),01444'9=82<.342C  2!!22222222222222222222222222222222222222222222222222CPoor recycling of BACE1 enzyme could promote Alzheimer\'s diseasev" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?3җ<֠Hd$װϕHF* \I^v"ZV ($hd*'eFRV2y`3hp#㝿M޶*';Me*pz֍4y !ci?Z9f$Mw.Ϩ*UTTւEV`/j|otUӛ=O@#`{_O QH \#-PC գˤ@fj8c`3uRqS\öṩAJOnnVȢ8(aսQI@ףCJdJ,O}T=jʸϙԄ]QEQEQEQEQF)QE)@ 2pN*D P ў ۷Ӥ嬧(+I3Igs{~MV %=v8z8kE8:#Υ(' S.t5-YـQEU8 ևdG)j"g7>֟Q$3&9;@6^$wN@*t#QE1Q@ſ4ZWoF #ֿp)Su%ʄ݈*5uJΗ‡6^$KK跰I.H_CƧ>o{fۭ3),3k4 vQ\}s hKCG\ڸq 8rT.6Z:ŵfY 6Opy_íyΥF.e mާx[DH\Z6̾Tk%@'޼ot{]?VqtMuR8*֞C;_#)lq$=y8jGL%H[uRpv\i/,8Wc"P\qMʐ\G+,ʤW' =8sNTN@MCb*tђ3UKre$\;7\*5uo\,J$bNS4ձU;<{Г?ЊP~l׌;_[^;PɑNxNqjJnaӴ}-- K$3,9?JM>ѩ[&<2D꘏c-9-.NpMch.Ԍ:t it-Q-B~]kY+c$䏝(C5-vi0u +\cqic'6i Dm&t%-oF #ֿpx <. ^x vak.ŢC!M0^#G$Z[*2aY4ڸd6{oz<.OOc/C{o r|$sp99c)sxN1^xMZR` TnA^L[ [Pv/B ڕt!y=AYc}jLς0 soơ_Gh_hMyq8gR=2=i_8+ Jζ/iF>}=+Tѵ졺"mAg?)%\I4YGvocsW[Y*MI7wՏl/5OVwor:nmsHC+1[fA]Q]`o \H#y5l?>/]P殣tWxBG4.+1g1@0{XO'\ӗ f S8$^>%rKTq,my>sEC٪e2z*7>CK[,Ȓ:-U]gZkۢ F;@8|V,4Uϼ:xڑ;1dW-G˧b: J yˌэ7'-1sMJ;˘ѴQo lq9gZ m><Wy9:/dqO3ʞYF[=\ g6C^)($H7H־giXj o¡14z%wWkw6kJJ8$pk=#f8ʎN;F;'箧jz'#zʤ7\dtr7FI bwc[#Ѯ4}]yVU=ޣu6b=[^~0ϧ*A5?gӿmpj҇sHS*PxmW' *QOu2\;W*xk y b'3+Q)dL_4E 5I €A$DFxqrF?,ƂK$wH__C*KӚp^,cQXmZ0mEu׺u֟.BeghQKDvrwxͯ]E`z_ڿ4{պYG7(s^eEnd!3⾆}.LFMb|9WKupr#Z>o.lcF\)ֹ_1\$0Sz] k*NJɒp=+?ź]χHDRJ@YO1#NJ/UwwhtiYHv{G}gvErלj;lxFIǵHaޢHOjU_Uw`ZcM&w1MeI^JrN%JF}OqL,vg!M^u ( QIJ(іɠ##|݇j掖R d۴(/h:oUI.Vϭxxz+=xΜ{=zƱc^y6 $!wJlw#ZαgI@ 88+־!fGӭ$3R=5\n`2ZR\Q:-Kۜ=&o2S?'Z;r mHhB?&[`v'>^5g]5dlw*]4*􏋠iU5KJKQd(5 \q!ȨsEaR.f5QEf2X&1JgLnܘ'&]Ǧk*e|%׎qYpaHhEȥO-hz#hǿ&ެiyse*Ojz_A _^\s6svI]Tb?<{OnFz7sf4J-^fRMX?5[IbG VGg"j:Ec3)P0@<5͹/jZ}d;X{g\pZ9'**-RJU.=30`?h/ެ3p}62U[c˿ p';QEZْ6a3f#GI"? xfߏ?EˇwIz?G6q?VF6˟g(̘Š+ӠX4;Bq,k+źerm9?{EywIIcM!Perº_jW`YեIC'ER)ٳӌ[ZŹI.ZX,7dJ:l?EQړǠ|ZOY?n9>Ƽ.𢊸7i$iՇ\ߏ?G\ߏ?Ee3e3Q@\ߏ?G\ߏ?Ee3e3Q@>(𯈗rd7QEeO◯˷2|jfdvIi]Ia}(kEJE#IoR߈&}OUeF9e >- s (IY=MԟQE,[MRV? endstream endobj 4 0 obj << /Type /XObject /Subtype /Form /FormType 1 /Filter /FlateDecode /BBox [0.000000 0.000000 595.276000 76.535433] /Matrix [1 0 0 1 0 0] /Resources << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F2 5 0 R /F1 3 0 R >> /XObject << /I0 20 0 R >> >> /Length 197 >> stream xKkBA WeI&ڊU/ nʥBf8A3!(X4`JQj*Aj͕197f hkL[=µrw]F D%x2WC0 9)Z ^Wh}29yyu?4g=bT1߻a endstream endobj 2 0 obj << /ProcSet [/PDF /Text /ImageB /ImageC /ImageI] /Font << /F1 3 0 R /F2 5 0 R /F3 6 0 R >> /XObject << /XT4 4 0 R /I0 20 0 R /I1 21 0 R >> >> endobj 7 0 obj <> /H /I>> endobj 8 0 obj <> /H /I>> endobj 9 0 obj <> /H /I>> endobj 10 0 obj <> /H /I>> endobj 11 0 obj <> /H /I>> endobj 12 0 obj <> /H /I>> endobj 13 0 obj <> /H /I>> endobj 14 0 obj <> /H /I>> endobj 15 0 obj <> /H /I>> endobj 22 0 obj << /Title (Poor recycling of BACE1 enzyme could promote Alzheimer's disease) /Subject (Poor recycling of BACE1 enzyme could promote Alzheimer's disease) /Creator (Science X Network) /Producer (TCPDF 6.3.5 \(http://www.tcpdf.org\)) /CreationDate (D:20220812150726-04'00') /ModDate (D:20220812150726-04'00') /Trapped /False >> endobj 23 0 obj << /Type /Metadata /Subtype /XML /Length 4785 >> stream application/pdf Poor recycling of BACE1 enzyme could promote Alzheimer's disease Poor recycling of BACE1 enzyme could promote Alzheimer's disease 2022-08-12T15:07:26-04:00 Science X Network 2022-08-12T15:07:26-04:00 2022-08-12T15:07:26-04:00 TCPDF 6.3.5 (http://www.tcpdf.org) uuid:c0378a8d-8a67-f184-fa88-2f9714c45876 uuid:c0378a8d-8a67-f184-fa88-2f9714c45876 http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal Adobe PDF Schema InstanceID URI http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text endstream endobj 24 0 obj << /Type /Catalog /Version /1.7 /Pages 1 0 R /Names << >> /ViewerPreferences << /Direction /L2R >> /PageLayout /SinglePage /PageMode /UseNone /OpenAction [16 0 R /FitH null] /Metadata 23 0 R >> endobj xref 0 25 0000000000 65535 f 0000004392 00000 n 0000017386 00000 n 0000004459 00000 n 0000016885 00000 n 0000004565 00000 n 0000004676 00000 n 0000017543 00000 n 0000017785 00000 n 0000018033 00000 n 0000018285 00000 n 0000018539 00000 n 0000018793 00000 n 0000019037 00000 n 0000019323 00000 n 0000019608 00000 n 0000000015 00000 n 0000000518 00000 n 0000003057 00000 n 0000003542 00000 n 0000004790 00000 n 0000010426 00000 n 0000019826 00000 n 0000020354 00000 n 0000025222 00000 n trailer << /Size 25 /Root 24 0 R /Info 22 0 R /ID [ ] >> startxref 25432 %%EOF